Clinical trial · Interventional
A New Method for Colorectal Cancer Screening: Colon Capsule Endoscopy Compared to Conventional Endoscopy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Introduction: Prevention of colorectal cancer (CRC) is feasible through polypectomy on screening colonoscopy. Patient acceptance remains the main limiting factor for execution. Colon capsule endoscopy (CCE) might be a novel method for large populations. Aims and methods: Patients referred for screening means or lower gastrointestinal complaints were included in this single center pilot study. They underwent preparation and then ingested the capsule (PillCam Colon). Standard colonoscopy was performed the next morning. Significance was defined as polyps \>5mm in size. Performance of exams was by independent physician with blinding of results.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colon capsule endoscopy | Procedure | — | UNRESOLVED |
| Conventional Colonoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Colon capsule endoscopy and colonoscopy
- description
- Patients underwent CCE on day 1 and conventional colonoscopy on day 2
- interventionNames
- Procedure: Colon capsule endoscopy
- Procedure: Conventional Colonoscopy
Primary outcomes (1)
- measure
- The primary endpoint was the number of cancerous lesions and polyps detected on CCE compared to conventional colonoscopy
- timeFrame
- 7 Months
Secondary outcomes (1)
- measure
- Secondary endpoints were completeness of the exam completeness, patient acceptance and adherence to preparation regimen
- timeFrame
- 7 Months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * male/female above the age of 50 years with symptoms (Indication for screening) * male/female above the age of 50 years without symptoms * male/female younger than 50 years without symptoms but with a positive family history for colorectal cancer (CRC) (Indication for screening) Exclusion Criteria: * CRC in the patient's history * cardiac pacemaker * contraindications for sodium phosphate solution (Colophos®) * risk factors for capsule retention including surgical intestinal anastomosis, Crohn's disease, diverticulitis and radiologically suspected bowel obstruction
References
Publications (1)
- DERIVEDPilz JB, Portmann S, Peter S, Beglinger C, Degen L. Colon Capsule Endoscopy compared to Conventional Colonoscopy under routine screening conditions. BMC Gastroenterol. 2010 Jun 18;10:66. doi: 10.1186/1471-230X-10-66. PMID 20565828