Clinical trial · Observational
MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer
A Pilot Study of Functional Mapping and Brain Perfusion Imaging in Patients Receiving Base of Skull and Brain Radiotherapy: Developing Neurocognitive Functional Organs At Risk for Individualized Conformal Radiotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Diagnostic procedures, such as specialized types of magnetic resonance imaging (MRI), may help in planning radiation therapy that does less damage to normal tissues. PURPOSE: This phase I trial is studying using functional MRI to see how well it works in planning radiation therapy in patients undergoing radiation therapy to the base of the skull and/or brain for nonmetastatic head and neck cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| blood-oxygen-level-dependent functional magnetic resonance imaging | Procedure | — | UNRESOLVED |
| diffusion tensor imaging | Procedure | — | UNRESOLVED |
| dynamic contrast-enhanced magnetic resonance imaging | Procedure | — | UNRESOLVED |
| functional magnetic resonance imaging | Procedure | — | UNRESOLVED |
| intensity-modulated radiation therapy | Radiation | — | UNRESOLVED |
| radiation therapy treatment planning/simulation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Feasability, as assessed by the proportion of study patients with functional regions identified within the brain as receiving exit irradiation
- timeFrame
- 90 days
Secondary outcomes (2)
- measure
- Summary parameters of the dose volume histograms to the functional regions identified
- timeFrame
- One year
- measure
- Cerebral blood flow and blood volume quantitated by relative measures normalized to regions of the brain not receiving any irradiation
- timeFrame
- 90 days
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically confirmed head and neck cancer that requires radiotherapy to the base of the skull * No evidence of metastatic disease PATIENT CHARACTERISTICS: * ECOG performance status 0-1 * Life expectancy ≥ 1 year * Not pregnant * Negative pregnancy test * Able to undergo standard CT simulation and radiotherapy treatment planning and delivery, including the capacity to comply with standard immobilization devices to the head and neck for daily irradiation * Able to undergo standard MRI and deemed capable of complying with the immobilization needs and tasks required for functional MRIs * No claustrophobia * No patients with pacemakers, metal fragments in the eye, or certain metallic implants PRIOR CONCURRENT THERAPY: * Not specified
References
Publications (0)
Data not yet available