Bone Graft Materials Observational Registry

Inclusion Criteria:

* The patient has failed conservative treatment and is a candidate for spinal fusion surgery.
* The patient is ≥18 years old and of legal age of consent.
* The patient is, in the investigator's opinion, psychosocially, mentally, and physically able to fully comply with this protocol, including the post-operative regimen, required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent.
* The patient is skeletally mature (epiphyses closed).
* The patient has signed the IRB approved informed consent.
* The patient is willing and able to participate in post-operative clinical and radiographic follow up evaluations for 2 years.

Exclusion Criteria:

* Patient has systemic infection or infection at the surgical site.
* Patient has a medical condition that would interfere with post-operative assessments and care (i.e., neuromuscular disease, psychiatric disease, paraplegia, quadriplegia, etc.).
* Patient is in poor general health or any concurrent disease process that would place the patient in excessive risk to surgery (i.e., significant circulatory or pulmonary problems, or cardiac disease).
* Patient has a history (present or past) of substance abuse (recreational drugs, prescription drugs or alcohol) that in the investigator's opinion may interfere with protocol assessments and/or with the patient's ability to complete the protocol required follow-up.
* The patient is pregnant/breastfeeding at the time of enrollment, or plans to become pregnant during the course of the study.
* Patient is participating in another investigational study, which could confound results.