Endostar Combined With CHOP Regimen as First Line Chemotherapy for Peripheral T Cell Lymphoma

Inclusion Criteria:

* Disease Characteristics:

  * Diagnosis of peripheral T-cell:

    * Any stage disease allowed
  * At least 1 objective measurable disease parameter
  * No anaplastic lymphoma kinase (ALK)-positive T-cell large cell lymphoma

    * ALK-negative T-cell large cell lymphoma allowed
  * No cutaneous T-cell lymphoma

    * No sezary syndrome
    * No NK/T cell lymphoma
  * No history of or current radiographic evidence of CNS metastasis, including previously treated, resected, or asymptomatic brain lesions or leptomeningeal involvement
* Patient Characteristics:

  * Age:

    * 18 -75 years
  * Performance status:

    * ECOG 0-2
  * Life expectancy:

    * No less than 12 weeks
  * Hematopoietic:

    * Absolute neutrophil count ≥ 1,500/mm\^3
    * Hemoglobulin ≥ 80\*10\^12/L
    * Platelet count ≥ 100,000/mm\^3
    * No evidence of bleeding diathesis or coagulopathy
  * Hepatic:

    * Bilirubin ≤ 1.5 mg/dL
    * AST ≤ 2.5 times ULN
    * PT, INR, and PTT ≤ 1.5 times normal
  * Renal:

    * Creatinine ≤ 1.5 times normal
  * Cardiovascular:

    * No cerebrovascular accident within the past 6 months
    * No myocardial infarction within the past 6 months
    * No unstable angina within the past 6 months
    * No New York Heart Association class II-IV congestive heart failure
    * No uncontrolled hypertension (i.e., systolic blood pressure \[BP\] \> 150 mm Hg or diastolic BP \> 100 mm Hg)
    * No other clinically significant cardiovascular or peripheral vascular disease
    * LVEF is normal
  * Other:

    * Not pregnant or nursing
    * Fertile patients must use effective contraception
    * No history of active seizures
    * No non-healing ulcer (unless involved with lymphoma)
    * No active infection requiring parenteral antibiotics
    * No known HIV positivity
    * No other active malignancy within the past 6 months except carcinoma in situ of the cervix or basal cell carcinoma of the skin
* PRIOR CONCURRENT THERAPY:

  * Biologic therapy:

    * Not specified
  * Chemotherapy:

    * No prior chemotherapy was allowed
  * Surgery:

    * More than 4 weeks since prior major invasive surgery or open biopsy
    * At least 7 days since prior minor surgery
    * No concurrent major surgery

Exclusion Criteria:

* Prior treatment included chemotherapy and radiotherapy
* With the following risk factors: Uncontrolled or severe cardiovascular disease (e.g., myocardial infarction within the past 6 months, congestive heart failure treated with medications, or uncontrolled hypertension)
* Pregnant or nursing
* Other currently active malignancy except nonmelanoma skin cancer
* Uncontrolled or severe bleeding,diarrhea,intestinal obstruction
* Hypersensitivity to albumen