Clinical trial · Interventional
Spinal Cord Compression Re-Treat Study
A Phase II Trial Evaluating the Efficacy of a Radio-Biological Based Re-Irradiation Strategy for Patients With Malignant Spinal Cord Compression
NCT00974168CI-TRIAL-00039765completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiation therapy to the spine. PURPOSE: This phase II trial is studying radiation therapy in treating patients with malignant spinal cord compression.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pain | — | UNRESOLVED | — |
| Radiation Toxicity | — | UNRESOLVED | — |
| Spinal Cord Compression | — | UNRESOLVED | — |
| Unspecified Adult Solid Tumor, Protocol Specific | Adult Solid Neoplasm | ALIAS | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cumulative BED ≤ 100 | Radiation | — | UNRESOLVED |
| Cumulative BED ≤ 130 Gy2 | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- A
- description
- Radiation Cumulative BED ≤ 100 Gy2
- interventionNames
- Radiation: Cumulative BED ≤ 100
- type
- ACTIVE_COMPARATOR
- label
- B
- description
- Cumulative BED ≤ 130 Gy2
- interventionNames
- Radiation: Cumulative BED ≤ 130 Gy2
Primary outcomes (2)
- measure
- Response to treatment as assessed by mobility via the Tomita mobility scale
- timeFrame
- 5 weeks after completion of radiation therapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * MRI-confirmed diagnosis of malignant spinal cord compression * MRI of the entire spine performed * Histologically proven malignancy * No primary tumors of the spine or vertebral column * Undergone previous radiotherapy to the involved area of the spinal cord (e.g., full segment and/or ≥ 2 cm in cranio-caudal of overlap between the 2 areas treated) * Maximum biologically effective dose received from previous irradiation ≤ 90 Gy\_2 * Deemed not suitable for neurosurgical intervention at the time of initial assessment * Patients deemed inoperable are eligible PATIENT CHARACTERISTICS: * Karnofsky performance status 40-100% * Short life expectancy * No medical or psychiatric condition that, in the opinion of the investigator or research team, contraindicates participation in this study PRIOR CONCURRENT THERAPY: * See Disease Characteristics
References
Publications (1)
- DERIVEDWallace ND, Dunne MT, McArdle O, Small C, Parker I, Shannon AM, Clayton-Lea A, Parker M, Collins CD, Armstrong JG, Gillham C, Coffey J, Fitzpatrick D, Salib O, Moriarty M, Stevenson MR, Alvarez-Iglesias A, McCague M, Thirion PG. Efficacy and toxicity of primary re-irradiation for malignant spinal cord compression based on radiobiological modelling: a phase II clinical trial. Br J Cancer. 2023 Feb;128(4):576-585. doi: 10.1038/s41416-022-02078-w. Epub 2022 Dec 8. PMID 36482188