Clinical trial · Interventional
Effect of Cinnamon Extract on Insulin Resistance in Polycystic Ovary Syndrome
Phase 1 Study That Will Compare 12 Weeks of Supplementation With Cinnamon Extract on the Action of Insulin and Blood Sugar (Glucose) With 12 Weeks of Supplementation With a Placebo.
NCT00970541CI-TRIAL-00053511EccentricterminatedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Recruitment
Summary
Brief summary (as posted)
The purpose of this study is to determine whether Cinnamon from the Cassae Plant is effective in the body as insulin could lower blood sugar levels.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Insulin Resistance | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cinnamon Supplementation | Dietary Supplement | — | UNRESOLVED |
| Placebo (wheat flour) | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Cinnamon Supplementation
- description
- A 500mg (consumed as two, 250mg capsules) of cinnamon extract (Cinnamon Bark P.E\> 20:1) will be consumed before meals, three times per day.
- interventionNames
- Dietary Supplement: Cinnamon Supplementation
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- A 500 mg placebo (wheat flour) will be consumed before meals, three times per day.
- interventionNames
- Dietary Supplement: Placebo (wheat flour)
Primary outcomes (1)
- measure
- Insulin sensitivity measured by the euglycemic hyperinsulinemic clamp
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * 20 to 40 years of age * Have a body mass index 25-40 kg/m2 * Have a sedentary lifestyle (participated in less than 30 minutes of physical activity 3 days per week over the last 6 months) * History of irregular menstrual cycles (fewer than 6 cycles in past year) * Excess androgen (to be measured at screening) * Willing to supplement normal diet with cinnamon extract and a placebo for 12 weeks * You can stay overnight at Pennington Center three times over the next six months Exclusion Criteria: * Do not meet our diagnostic criteria for polycystic ovary syndrome * Have heart disease, lung disease, liver disease, blood disease, kidney disease, type 1 or 2 diabetes, or any other disease that in the opinion of the doctor might make you ineligible. * Have cancer (active malignancy with or without concurrent chemotherapy). * Abuse alcohol or illegal drugs. * Smoke or have smoked within the previous 6 months. No smoking will be permitted during the study. * Have donated blood within 30 days prior to randomization date. * Have a hemoglobin, hematocrit, red blood cell, or iron level below the normal lower limit at screening. * Taking medications that alter your glucose metabolism, (30 minute or more, 4 or more times per week over the past year.) * Unwilling or unable to adhere to the clinical evaluation schedule over the entire six-month follow-up period.
References
Publications (0)
Data not yet available
No reference posted for this study.