Clinical trial · Interventional
Endoscopic Ultrasound (EUS) Guided-Celiac Plexus Neurolysis (CPN) in Unresectable Pancreatic Cancer
EUS Guided-Celiac Plexus Neurolysis (CPN) for Patients With Unresectable Pancreatic Cancer: A Multi-Center, Randomized, Single-Blinded Controlled Trial
NCT00968175CI-TRIAL-00014778completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to examine endoscopic ultrasound guided celiac plexus neurolysis (CPN) with analgesic therapy in patients with unresectable pancreatic cancer as it applies to decreasing the severity of abdominal pain when compared to analgesic therapy alone.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pain | — | UNRESOLVED | — |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ultrasound guided celiac plexus neurolysis (CPN) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Group 1: CPN + analgesic therapy
- description
- Receives ultrasound guided celiac plexus neurolysis (CPN) in addition to standard analgesic therapy
- interventionNames
- Procedure: Ultrasound guided celiac plexus neurolysis (CPN)
- type
- NO_INTERVENTION
- label
- Analgesic therapy alone
- description
- Will not receive ultrasound guided celiac plexus neurolysis (CPN); only standard analgesic therapy for pain management
Primary outcomes (1)
- measure
- The efficacy of EUS-CPN and analgesic therapy in pain relief of patients with unresectable pancreatic cancer when compared with analgesic therapy
- timeFrame
- ~ 2 year
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1. Male or Female 2. Age ≥19 yrs old 3. Abdominal pain typical for pancreatic cancer ≥3/10 4. Abdominal CT radiologically consistent with the diagnosis of pancreatic cancer 5. Pancreatic cancer confirmed by FNA during EUS 6. Inoperability of pancreatic cancer as determined during EUS or prior CT Exclusion Criteria: 1. Age \< 19 yrs old 2. Unable to safely undergo EUS for any reason 3. Coagulopathy (prolongation of prothrombin time \> 18 sec, thrombocytopenia \<80,000 platelets/ml) 4. Previous CPN or other neurolytic block that could affect pancreatic cancer -related pain or had implanted epidural or intrathecal analgesic therapy 5. Another cause for abdominal pain such as pseudocyst, ulcer or other intra-abdominal disorder 6. Potential patient noncompliance (refusing to follow schedule of events) 7. Active alcohol or other drug use or significant psychiatric illness 8. Pregnant or breastfeeding 9. Unable to consent 10. Non-English speaking
References
Publications (0)
Data not yet available
No reference posted for this study.