Panobinostat (LBH589) Plus Everolimus (RAD001) in Patients With Relapsed and Refractory Lymphoma

Inclusion Criteria:

1. Histologically confirmed Hodgkin or non Hodgkin's lymphoma
2. Relapsed or refractory after standard treatments and with no curative option with conventional therapy
3. No evidence of cerebral or meningeal involvement by lymphoma
4. Age \>= 18 years
5. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2
6. Life expectancy of at least 3 months
7. Signed informed consent form prior to enrollment
8. Patients must meet the following laboratory criteria: Aspartate aminotransferase (AST)/serum glutamate oxaloacetate transaminase (SGOT) and ALT/serum glutamate pyruvate transaminase (SGPT) \</= 2.5 \* upper limit of normal (ULN) ) or \</= 5.0 x ULN if the transaminase elevation is due to lymphoma involvement, Serum bilirubin \</= 1.5 \* ULN, Serum creatinine \</=1.5 \* ULN free T4 within normal limits (WNL) (patients may be on thyroid hormone replacement)
9. Patients must have at least one measurable site of disease
10. Adequate bone marrow function as shown by: Absolute neutrophil count (ANC) \>/= 1.0 x 109/L, Platelets \>/=100 x 109/L
11. Fasting serum cholesterol \</=300 mg/dL OR \</=7.75 mmol/L AND fasting triglycerides \</= 2.5 \* ULN. NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication 24 hours before starting therapy.
12. Women of childbearing potential (WOCBP) must have a negative serum pregnancy test within 7 days of the first administration of study drug

Exclusion Criteria:

1. Burkitt's lymphoma, Lymphoblastic lymphoma, Chronic lymphocytic leukemia (Small lymphocytic lymphoma may be included)
2. Chemotherapy or radiation therapy or other investigational agents within 4 weeks prior to entering the study
3. Previous radioimmunotherapy within 12 weeks
4. Prior therapy with HDAC or \[1\] mammalian target of rapamycin (mTOR) inhibitors i.e. temsirolimus, vorinostat (the list is not inclusive of investigational agents in these classes of drugs)
5. Patient with known HIV infection
6. Known active viral hepatitis
7. Any serious active disease or co-morbid condition, which in the opinion of the principle investigator, will interfere with the safety or with compliance with the study
8. Impaired cardiac function including any one of the following: • Screening ECG with a corrected QT interval (QTc) \> 450 msec confirmed by the investigator prior to enrollment to the study • Patients with congenital long QT syndrome • History of sustained ventricular tachycardia • Any history of ventricular fibrillation or torsades de pointes • Bradycardia defined as heart rate \< 50 beats per minute. Patients with a pacemaker and heart rate \>= 50 beats per minute are eligible.
9. Impaired cardiac function including any one of the following continued: • Patients with a myocardial infarction or unstable angina within 6 months from registration on study • Congestive heart failure (NY Heart Association class III or IV) • Right bundle branch block and left anterior hemiblock (bifascicular block) • Uncontrolled hypertension
10. Concomitant use of drugs with a risk of causing torsades de pointes
11. Patients with unresolved diarrhea Common Toxicity Criteria for Adverse Effects (CTCAE) grade 1
12. Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral PANOBINOSTAT or everolimus.
13. Female patients who are pregnant or breast feeding, or adults of reproductive potential who are not using effective birth control methods. If barrier contraceptives are being used, these must be continued throughout the trial by both sexes. Hormonal contraceptives are not acceptable as a sole method of contraception.
14. Male patients whose sexual partners are WOCBP not using effective birth control
15. Patients with a history of another primary malignancy within 5 years other than curatively treated CIS of the cervix, basal or squamous cell carcinoma of the skin, or early stage prostate carcinoma.
16. Patients with known positivity for human immunodeficiency virus (HIV) ) or hepatitis C; baseline testing for HIV and hepatitis C is not required
17. Patients with any significant history of non-compliance to medical regimens or with inability to grant a reliable informed consent
18. Patients receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent, except corticosteroids with a daily dosage equivalent to prednisone \<= 20 mg. Topical or inhaled corticosteroids are allowed.
19. Patients should not receive immunization with attenuated live vaccines within one week of study registration or during study period
20. Chronic obstructive pulmonary disease (COPD) or asthma requiring therapy
21. Uncontrolled diabetes as defined by fasting serum glucose \>1.5 x ULN
22. Active (acute or chronic) uncontrolled severe infection, requiring oral or intravenous antibiotics.
23. Patients receiving treatment on another clinical research trial.