A Study of MK-2206 in Combination With Trastuzumab and Lapatinib for the Treatment of HER2+ Solid Tumors (MK-2206-015)

Inclusion Criteria:

* Have a histologically or cytologically-confirmed locally advanced or metastatic HER2+ solid tumor.
* Have performance status ≤1 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale.
* Have adequate organ function.
* Female participants have a negative pregnancy test 72 hours prior to receiving the first dose of study medication.
* Have completed any major surgery for a minimum of 28 days prior to enrollment in this study.
* Able to swallow tablets and has no surgical or anatomical condition that will preclude the patient from swallowing or absorbing oral medications on an ongoing basis.

Exclusion Criteria:

* Had chemotherapy, radiotherapy or biological therapy within 4 weeks of screening. Participants receiving trastuzumab and/or lapatinib prior to screening must be off both medications for 1 week prior to first dose of MK-2206 if trastuzumab had been administered at 2 mg/kg weekly and 3 weeks if trastuzumab had been administered at 6 mg/kg weekly.
* Currently participating or has participated in a study with an investigational compound or device within 30 days, or 5x half-life from prior agents, whichever is longer, of Day 1 of this study
* Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
* Has a primary CNS tumor.
* Has known hypersensitivity to the components of study drugs or its analogs.
* Has a history or evidence of heart disease.
* Has uncontrolled hypertension or diabetes.
* Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
* Is pregnant or breastfeeding or is expecting to conceive or father children during the study.
* Is HIV positive.
* Has symptomatic ascites or pleural effusion.
* Is receiving treatment with oral corticosteroids for reason other than CNS metastasis.