Clinical trial · Observational
Metabolism of Lipids in Advanced Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): ethics approval not renewed by Study Group
Summary
Brief summary (as posted)
The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cachexia | — | UNRESOLVED | — |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood draws | Other | — | UNRESOLVED |
| Metabolic rate testing | Procedure | — | UNRESOLVED |
| Oral administration of stable isotope (deuterium) | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Metabolism
- description
- Lung cancer patients who exhibit abnormalities in lipid measures.
- interventionNames
- Other: Blood draws
- Biological: Oral administration of stable isotope (deuterium)
- Procedure: Metabolic rate testing
Primary outcomes (1)
- measure
- Rate of hepatic de novo lipogenesis
- timeFrame
- 9 months
Secondary outcomes (2)
- measure
- Measures of fat transport and availability
- timeFrame
- 9 months
- measure
- Resting metabolic rate & fat oxidation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Low plasma phospholipids OR low plasma ratio of triglycerides to free fatty acids * Recent weight loss * Advanced stage lung cancer (Stage 3 or 4) Exclusion Criteria: * Having symptoms that may affect measures of fat metabolism (nausea, vomiting, problems swallowing, etc.) * Taking n-3 fatty acid supplements such as fish oil
References
Publications (0)
Data not yet available