Clinical trial · Interventional
In Vivo Confocal Endomicroscopy of the Brain
NCT00949793CI-TRIAL-00002766completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study is to test the feasibility of obtaining interpretable in vivo endomicroscopy images which can be compared with traditional histopathology. Hypothesis: That a rigid confocal endomicroscope can be used during neurosurgery to provide in vivo histology that enables differentiation of tumour tissue from normal adjacent brain tissue.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endomicroscope | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- All patients
- interventionNames
- Device: Endomicroscope
Primary outcomes (1)
- measure
- To test of the ability of the surgeon to obtain interpretable images during surgery.
- timeFrame
- During surgery
Secondary outcomes (2)
- measure
- To correlate the in vivo endomicroscopy images with traditional histopathology.
- timeFrame
- one week
- measure
- To evaluate the usability of the device in the OR environment.
- timeFrame
- During surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients with neurosurgical pathology requiring surgery in which tumor resection might be evaluated by using biopsy. Exclusion Criteria: * Pregnant women * Inability to give informed consent * History of allergy to fluorescein * Patients on beta-blockers or ACE inhibitors
References
Publications (0)
Data not yet available
No reference posted for this study.