Clinical trial · Interventional
A Pilot Study of Ultra Rapid Opioid Rotation and Titration of Oxymorphone
NCT00945919CI-TRIAL-00002489unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This project will explore the safety and feasibility of performing a successful intravenous patient controlled analgesia (IV PCA) Oxymorphone titration and conversion to oral ER Oxymorphone (extended release or OPANA ER) in the outpatient setting.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Nociceptive Pain | — | UNRESOLVED | — |
| Neuropathic Pain | — | UNRESOLVED | — |
| Non-cancer Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oxymorphone ER | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The safety of rapid Opioid rotation
- timeFrame
- Daily for two weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years of age or older. * Chronic pain of nociceptive, neuropathic, or mixed origin. * Patients with chronic non-cancer pain. * Ongoing chronic Opioid treatment with either oral morphine or oxycodone (long term-more than three months and at least a total daily Opioid dose of 60mg morphine or of 30 mg oxycodone). * Pain of moderate intensity (\>= 4, on the numerical scale 0-10) despite ongoing Opioid therapy. * Non-pregnant, non-lactating women. * Sufficient language skills to communicate with research staff. Exclusion Criteria: * Non-ambulatory patients. * Clinically significant respiratory, renal, hepatic, or cardiac disease. * Documented diagnosis of sleep apnea (the study physician may exclude patients who present with clinical features and complaints suggestive of a diagnosis of probably sleep apnea). * History of illicit drug or alcohol dependence or abuse, abnormal drug taking/seeking behaviors. * Sever depression (\> 26 on the BDI) or severe anxiety or insomnia requiring chronic daily use of benzodiazepines or hypnotic drugs. * Patients who exhibit a score on the Mini Mental Status Exam (MMSE) of 26 or less. (The range of scores for mild dementia is 21-26 on the MMSE). * Hypersensitivity to study medication (Oxymorphone).
References
Publications (0)
Data not yet available
No reference posted for this study.