Clinical trial · Interventional
Comparing Local Anesthesia With General Anesthesia for Breast Cancer Surgery
A Comparison of Local Anesthesia and General Anesthesia for Breast Cancer Surgery, a Prospective Randomized Trial
NCT00938171CI-TRIAL-00002460unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine therapeutic benefits by local anesthetic technique for breast cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| General anesthesia | Procedure | — | UNRESOLVED |
| Local anesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- local anesthesia
- description
- local anesthesia with propofol sedation Target-controlled infusion (TCI) system will be used to maintain proper sedation level)
- interventionNames
- Procedure: Local anesthesia
- type
- ACTIVE_COMPARATOR
- label
- General anesthesia
- description
- Patients receiving general anesthesia
- interventionNames
- Procedure: General anesthesia
Primary outcomes (1)
- measure
- Visual Analog Scale (VAS) pain scores
- timeFrame
- Until PACU discharge and for 24 hours
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 21 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Biopsy-proven breast cancer Scheduled for mastectomy and axillary node dissection in a single procedure. Exclusion Criteria: * previous surgery within the preceding 2 wk those other than ASA physical status I or II any contraindication to either local anesthesia or opioid analgesia
References
Publications (1)
- DERIVEDNunez-Rodriguez E, Zhang H, Sah D, Cata JP. Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? Adv Biol (Weinh). 2025 Oct;9(10):e00122. doi: 10.1002/adbi.202500122. Epub 2025 Aug 7. PMID 40772525