Clinical trial · Interventional
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Does Low-frequency Electro-acupuncture Restore Sensitivity of the Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
NCT00921492CI-TRIAL-00034362PCOSLFEAcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Hypothesis The overall hypothesis is that non-obese (BMI \<30) women with PCOS have high luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated low-frequency EA restore these alterations and induce ovulation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low-frequency electro-acupuncture (EA) | Device | — | UNRESOLVED |
| Meeting a therapist - attention control | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Low-frequency electro-acupuncture
- interventionNames
- Device: Low-frequency electro-acupuncture (EA)
- type
- ACTIVE_COMPARATOR
- label
- Meeting a therapist - attention
- interventionNames
- Other: Meeting a therapist - attention control
Primary outcomes (1)
- measure
- Frequent blood sampling every 10th minute during an overnight stay in order to measure changes in LH and cortisol pulsatility before and after treatment. A third assessment will be made in those participants who ovulate during the 14 week study.
- timeFrame
- 16 weeks
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 39 Years
Show eligibility criteria text
Inclusion Criteria: * 18 - 39 years, inclusive * 30 ≤ BMI * History of irregular menstrual cycles * Clinical and/or biochemical androgen excess (determined during screening) Exclusion Criteria: Medical Exclusion Criteria * History or clinical manifestation of; cardiovascular disease, diabetes (Type 1 or Type 2), any other significant endocrine or metabolic disorder. * Regular use of medications for weight control, psychosis and thyroid disease. A 3 month washout period will be permitted for contraceptives. Psychiatric and Behavioral Exclusion Criteria * Pregnant or breast-feeding women
References
Publications (1)
- DERIVEDJohansson J, Redman L, Veldhuis PP, Sazonova A, Labrie F, Holm G, Johannsson G, Stener-Victorin E. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E934-43. doi: 10.1152/ajpendo.00039.2013. Epub 2013 Mar 12. PMID 23482444