A Clinical Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SRT501 in Subjects With Colorectal Cancer and Hepatic Metastases

Inclusion Criteria:

* Be male or female greater than 18 years of age.
* Have histologically or cytologically confirmed and diagnosed colorectal cancer with hepatic metastases.
* Have not received chemotherapy or anti-neoplastic therapy for a malignancy within six weeks of first dose of SRT501 or placebo.
* Have a life expectancy of greater than 3 months.
* Voluntarily sign an Ethics Committee (EC)-approved informed consent form (ICF) to participate in the study after all relevant aspects of the study have been explained and discussed with the subject.
* Be deemed, in the Investigator's opinion, to be able to physically comply with SRT501 dosing.
* Be amenable to surgical resection of the hepatic metastases.
* Be clear of any history of HIV 1 and 2 and hepatitis B and C.
* Have a normal 12-lead ECG or an ECG with abnormality considered to be clinically insignificant.
* Have the ability to communicate with the investigative site staff in a manner sufficient to carry out all protocol procedures as described.
* Female subject is either post-menopausal, surgically sterilized or be a woman of child bearing potential (WCBP) who has documented use of clinically prescribed hormonal contraceptives use consistently for three months prior to study entry. Females of child bearing potential, as well as their partners, must also use appropriate double-barrier birth control while participating in the study and for 28 days following the last dose of study drug. If a woman of child bearing potential has a surgically sterile partner, then that female is permitted to enroll if double-barrier birth control is practiced.

Exclusion Criteria:

* Subject has a history / evidence of allergy or hypersensitivity to resveratrol.
* Subject has had a major illness (other than colorectal cancer) in the past three months or any significant ongoing chronic medical illness that the Investigator would deem unfavorable for enrollment.
* Subject has inadequate organ function at the Screening visit as defined by the following laboratory values:

  * Platelet count ≤100,000 x 10\^9/L
  * Hemoglobin ≤10.0 g/dL
  * Subjects with lower hemoglobin may be included at the Investigator's discretion if the cause of anemia is due to bleeding from their tumor and post transfusion hemoglobin ≥10g/dL prior to dosing.
  * Absolute neutrophil count (ANC) ≤1500 x 10\^6/L
  * Aspartate transaminase (AST) ≥2.5 x the upper limit of the normal range (ULN)
  * Alanine transaminase (ALT) ≥2.5 x ULN
  * Creatinine ≥ 140 umol/L
  * Albumin ≤3 g/dL
* Subject has a history of or current gastro-intestinal diseases influencing drug absorption, with the exception of an appendectomy and/or colorectal cancer.
* Subject has liver impairment as indicated by total bilirubin ≥2 x ULN, unless clearly related to the disease (ie, biliary occlusion due to tumor compression or confirmed Gilbert's Disease as documented by the Investigator).
* Subject had a myocardial infarction within 6 months prior to enrollment or has New York Hospital Association (NYHA) Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at Screening has to be documented by the investigator as not medically relevant.
* Excessive alcohol intake (more than UK recommended limit - 28 or 21 units per week for men or women respectively).
* Subject has uncontrolled brain metastases or central nervous system disease.
* Subject has participated in a clinical trial within the past three months.
* Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum beta-hCG pregnancy test result obtained during the Screening period. Pregnancy testing is not required for post-menopausal or surgically sterilized women.