Clinical trial · Observational
Study of Tumor Samples From Patients With Stage III Colon Cancer Who Have Undergone Surgery and Chemotherapy
Study of Biomarkers in Tissue Samples of Patients With Stage III Colon Cancer Treated With Adjuvant Chemotherapy Comprising Fluorouracil-Based Regimens(B-CAST)
NCT00918827CI-TRIAL-00027963completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer who have undergone surgery and chemotherapy may help doctors predict how well patients will respond to treatment. PURPOSE: This research study is looking at tumor samples from patients with stage III colon cancer who have undergone surgery and chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Relationship between expression levels of enzymes and disease-free survival, relapse-free survival, and overall survival
- timeFrame
- 5 years after the end of registration
- measure
- Relationship between expression levels of enzymes and adverse effects
- timeFrame
- 5 years after the end of registration
- measure
- Disease-free survival
- timeFrame
- Until the day on which an event reveals during the 5 year observational period
- measure
- Relapse-free survival
- timeFrame
- Until the day on which an event reveals during the 5 year observational period
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
\<Inclusion criteria\> * Pathologically confirmed stage III colon adenocarcinoma * Curatively resected (R0) * Patients scheduled for treatment with fluorouracil-based post-operative adjuvant chemotherapy * Provided written informed consent \<Exclusion criteria\> * Synchronous or metachronous multiple cancers * Contraindications for fluorouracil-based chemotherapy * Patients who have initiated neo-adjuvant chemotherapy or radiotherapy prior to participating in this study * Ineligible patients according to the investigator's judgement
References
Publications (1)
- DERIVEDIshiguro M, Kotake K, Nishimura G, Tomita N, Ichikawa W, Takahashi K, Watanabe T, Furuhata T, Kondo K, Mori M, Kakeji Y, Kanazawa A, Kobayashi M, Okajima M, Hyodo I, Miyakoda K, Sugihara K. Study protocol of the B-CAST study: a multicenter, prospective cohort study investigating the tumor biomarkers in adjuvant chemotherapy for stage III colon cancer. BMC Cancer. 2013 Mar 25;13:149. doi: 10.1186/1471-2407-13-149. PMID 23530572