Oxymorphone Extended Release in Patients With Cancer or Neuropathic Pain

Inclusion Criteria:

* ≥ 18 years of age or older, with moderate to severe chronic malignant and/or neuropathic pain of at least 3 months duration and either:

  1. have an initial pain intensity score of greater than 4 on a 10-point scale using BPI Question 5, if sub-optimally responding to their current analgesic regimen, or
  2. have intolerable side effects to one or more components of their current opioid-containing analgesic regimen.
* Currently receive a stable (at least 2 weeks duration) analgesic regimen
* If female, must be practicing abstinence or using a medically acceptable form of contraception (e.g., intrauterine device, hormonal birth control, or double barrier method).
* Understand written and spoken English
* Have been informed of the nature of the study and provided written informed consent

Additional Inclusion Criteria for Cancer Patients Only:

* Have a life expectancy of at least 12 months

Additional Inclusion Criteria for Neuropathic Patients Only:

* Have a diagnosis of:

  * post-herpetic neuralgia (PHN)
  * diabetic neuropathy (DN)
  * complex regional pain syndrome (CRPS)
  * HIV neuropathy
  * idiopathic sensory neuropathy
  * traumatic peripheral neuropathy
  * central neuropathic pain condition (spinal cord injury, post-stroke pain), OR
  * other peripheral neuropathy (upon mutual agreement of the sponsor and investigator).

Exclusion Criteria:

* Have a positive pregnancy test (females only)
* Have a history of or active asthma or emphysema
* Have clinically significant hepatic impairment
* Have a history of alcohol or substance abuse within the last 3 years
* Have a history of opioid abuse within 6 months prior to study entry
* Have a known allergy or significant reaction to opioids, including codeine
* Have a known oxymorphone sensitivity or allergy
* Have received an investigational drug or product or participated in an investigational drug study within a period of 30 days prior to receiving study medication