Neuradiab® Combined With Bevacizumab (Avastin) Therapy in Patients With Recurrent Glioblastoma Multiforme

Inclusion Criteria:

* Previous histopathology confirmed diagnosis of (World Health Organization \[WHO\] grade IV astrocytoma; (http://rad.usuhs.mil/rad/who/who2b.html)
* Patients with recurrent disease presenting as a supratentorial unifocal lesion seen on magnetic resonance imaging (MRI) suspicious for glioblastoma multiforme will be considered as long as:

  1. Patient is eligible for or has undergone a gross total surgical resection of the tumor mass with a residual ridge ≤ 1cm
  2. A post-operative MRI will be obtained within 72 hours of resection and must show an adequate resection defined by ≤ 1 cm enhancement.
* No evidence of hemorrhage on the baseline MRI or CT scan other than those that are postoperative grade 1.
* Age ≥ 18 years of age at the time of study entry.
* Karnofsky Performance Status ≥ 70%.
* Adequate bone marrow function
* Adequate hepatic function
* Adequate renal function
* Patient must be HAMA negative prior to study entry
* Able to tolerate standard post operative management for GBM debulking including corticosteroid therapy
* An interval of at least 30 days from prior chemotherapy (6 weeks for nitrosoureas) or investigational agent unless the patient has recovered from all anticipated toxicities associated with that therapy
* Women of childbearing potential must have a negative pregnancy test (serum or urine).
* The patient must agree to use an effective contraceptive method
* Patient must give written informed consent prior to any study-specific procedures being implemented

Exclusion Criteria:

* Infratentorial tumor, tumor with subependymal spread, multifocal tumor, tumor with ventricular communication, intraventricular tumor or tumor which is within one gyrus (approximately 1cm) of the motor/sensory strip, either of the speech centers, or exceeds beyond the cranial vault.
* Severe, active comorbidity, including any of the following:

  1. Unstable angina and/or congestive heart failure requiring hospitalization
  2. Transmural myocardial infarction within the last 6 months
  3. Acute bacterial or fungal infection requiring intravenous antibiotics at the time of study entry
  4. Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of study entry
  5. Known hepatic insufficiency resulting in clinical jaundice (excluding Gilbert's syndrome) and/or coagulation defects
  6. Known AIDS based upon current CDC definition
  7. Major medical illnesses or psychiatric impairments that, in the investigator's opinion, will prevent administration or completion of protocol therapy
  8. Active connective tissue disorders, such as lupus or scleroderma that, in the opinion of the treating physician, may put the patient at high risk for radiation toxicity.
* History of severe allergic reaction to contrast media.
* Any serious medical condition or psychiatric illness unresponsive to medical intervention.
* Prior malignancy if active treatment was required during the previous 3 years (except for adequately treated basal cell or squamous cell skin cancer and prior GBM)
* Known hypersensitivity to murine proteins.
* Inability to undergo an MRI.
* Patient has been treated with any anti-angiogenic therapy within 30 days prior to study entry
* Co-medication that may interfere with study results; e.g. immuno-suppressive agents other than corticosteroids