Controlled Trial Comparing Nomogram-based Versus Standard Allocation of Acute Normovolemic Hemodilution (ANH) During Hepatic Resection

Inclusion Criteria:

* Adults (\>18 years).
* Preoperative hemoglobin concentration ≥ 11 mg/dl (males), ≥ 10 mg/dl (females) within 14 days of registration.
* Patients scheduled for hepatic resection for any indication, with or without other planned procedures

Exclusion Criteria:

* A history of active coronary artery disease.
* Patients with a history of coronary artery disease will be eligible if they have had a cardiac stress study showing no reversible ischemia and normal LV function within 30 days of operation.
* Patients with active or symptomatic cerebrovascular disease; patients with hemodynamically insignificant stenosis will not be deemed ineligible.
* A history of congestive heart failure.
* A history of uncontrolled hypertension.
* A history of restrictive or obstructive pulmonary disease.
* A history of renal dysfunction (Cr \> 1.8).
* Abnormal coagulation parameters (INR \> 1.5 in patients not on coumadin; an INR\>1.5 is acceptable in patients still on coumadin, provided drug is discontinued no less than 4 days prior to operation.)
* Presence of active infection.
* Evidence of hepatic metabolic disorder (bilirubin \> 2 mg/dl, ALT \> 75 U/L in the absence of biliary tract obstruction).
* Pre-operative autologous blood donation.
* Erythropoietin use
* Patients scheduled for ablation only
* Pregnant or lactating females