Clinical trial · Observational
DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma
Comprehensive Molecular Analysis of Tumor Samples Derived From Patients With Diffuse Brainstem Glioma - A Pilot Study
NCT00899834CI-TRIAL-00023238completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This multi-institutional study will prospectively collect tumor and constitutional tissue samples from patients with diffuse brainstem glioma and other types of brainstem gliomas either during therapy or at autopsy to perform an extensive analysis of genetic and molecular abnormalities in these tumors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumors | Brain Neoplasm | ALIAS | 0.90 |
| Central Nervous System Tumors | Central Nervous System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Tumor Samples
- description
- fresh-frozen and fixed tumor samples and correspondent normal tissue from patients affected with this tumor.(peripheral blood is applicable only to patients with focal brainstem gliomas and patients who undergo biopsy of a diffuse brainstem glioma at diagnosis)
Primary outcomes (7)
- measure
- DNA gains and losses and RNA expression in tumor samples and normal tissue
- timeFrame
- at autopsy
- description
- Tissue samples will be obtained at autopsy.
- measure
- Genome-wide expression patterns of RNA in tumor samples and normal tissue as assessed by Affymetrix gene expression profiling
- timeFrame
- at autopsy
- description
- Tissue samples will be obtained at autopsy.
- measure
- Validation of results of the genome-wide analysis
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria * Patients of any age with clinical and radiologic diagnosis of diffuse brainstem glioma * Patients with other high-grade gliomas originating in the brainstem * Patients with focal gliomas (WHO grade I/II) of the brainstem * Enrollment in the current version of the St. Jude Tissue Bank protocol for patients whose tissue samples were obtained at diagnosis and who received treatment at St. Jude Children's Research Hospital (SJCRH), or correspondent tissue banking consent for patients treated in other institutions if tissue was obtained prior to death (as applicable, depending on the standard of each institution) Exclusion Criteria * Patients with any type of infiltrative low-grade (WHO grade II) or high-grade glioma (WHO grade III and IV) originating outside the brainstem * Patients harboring primary brainstem tumors with other histologic diagnoses (e.g., PNET)
References
Publications (0)
Data not yet available
No reference posted for this study.