Clinical trial · Observational
DNA Analysis of Tissue From Patients With T-Cell Acute Lymphoblastic Leukemia
Molecular Mechanisms of NOTCH Induced Transformation in T-ALL
NCT00899366CI-TRIAL-00043188completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at tissue samples from patients with T-cell acute lymphoblastic leukemia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| immunologic technique | Other | — | UNRESOLVED |
| microarray analysis | Genetic | — | UNRESOLVED |
| mutation analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Transcriptional signatures associated with NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) cells
- timeFrame
- 1 month
- description
- Mutational analysis
- measure
- Global changes on gene expression resulting from inactivation of NOTCH signaling in T-ALL cells
- timeFrame
- 1 month
- description
- Gene expression
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Confirmed diagnosis of T-cell acute lymphoblastic leukemia * Frozen lymphoblast samples available * NOTCH1-mutated or wild type sample available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified Exclusion Criteria: * Not applicable
References
Publications (0)
Data not yet available
No reference posted for this study.