Clinical trial · Observational
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer
Study of Diagnostic Tests Studying Kinetic Variation of Serum Matrix Metalloproteases After Surgical Treatment and/or Destruction by Radiofrequency in Patients With Hepatic Metastases From Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research trial is studying matrix metalloproteinases after surgery or radiofrequency ablation in patients with liver metastases from colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Metastatic Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cryosurgery | Procedure | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| radiofrequency ablation | Procedure | — | UNRESOLVED |
| therapeutic conventional surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Kinetics of postoperative changes of serum matrix metalloproteinases (MMP) and their inhibitors (TIMP)
Secondary outcomes (4)
- measure
- Predictive value of postoperative risk of recurrence
- measure
- Correlation of risk of recurrence with surgical technique
- measure
- Elevated serum levels of MMP vs carcinoembryonic antigen as a marker of hepatic or extrahepatic recurrence
- measure
- Correlation of postoperative serum HGF/SF with plasma levels in MMPs
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Meets 1 of the following criteria:
* Patients with histologically confirmed adenocarcinoma of the colon or rectum and liver metastases
* Must have undergone prior complete resection of the tumor more than 3 months ago
* Liver metastases must be resectable or accessible for radiofrequency ablation
* Patients undergoing cryosurgery of the digestive tract for a reason other than cancer or infection (control)
PATIENT CHARACTERISTICS:
* No other neoplastic disease that is measurable or being treated other than colorectal cancer
* No heart failure or severe respiratory disease
* No uncontrolled infection or other severe disease
PRIOR CONCURRENT THERAPY:
* See Disease Characteristics
* No participation in another study involving new drugsReferences
Publications (0)
Data not yet available