Clinical trial · Observational
Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer
Molecular Predictors of Lung Cancer Behavior
NCT00898313CI-TRIAL-00109488recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high risk of cancer for laboratory studies may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at molecular predictors of cancer in patients at high risk of lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (11)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biologic sample preservation procedure | Other | — | UNRESOLVED |
| Blood draw | Procedure | — | UNRESOLVED |
| comparative genomic hybridization | Genetic | — | UNRESOLVED |
| fine needle aspiration of the lung | Procedure | — | UNRESOLVED |
| fluorescence bronchoscopy with airway biopsy | Procedure | — | UNRESOLVED |
| gene expression microarray analysis | Genetic | — | UNRESOLVED |
| nasal brushing | Procedure | — | UNRESOLVED |
| proteomic profiling analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Sample Collection
- interventionNames
- Genetic: comparative genomic hybridization
- Genetic: gene expression microarray analysis
- Genetic: proteomic profiling analysis
- Other: biologic sample preservation procedure
- Procedure: nasal brushing
- Procedure: Blood draw
- Procedure: Urine collection
- Procedure: sputum sample
- Procedure: fluorescence bronchoscopy with airway biopsy
- Procedure: fine needle aspiration of the lung
- Procedure: thoracentesis
Primary outcomes (1)
- measure
- To quantitate the molecular changes during lung cancer development
- timeFrame
- After collection of designated samples
- description
- As a part of the study nasal brushing specimens, sputum, blood, urine, and a small amount of other tissue will be collected during standard of care procedures (bronchial epithelial, trans-thoracic fine needle aspiration (FNA) and thoracentesis as part of patient work up. Clinical diagnosis is the primary goal of the procedure. All the research specimens are collected after the primary goal of the procedure is met.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: -All adults referred to Vanderbilt Medical Center, Veterans Administration Medical Center, St. Thomas Hospital and Meharry Medical Center for evaluation of signs or symptoms of lung cancer. Exclusion Criteria: * Inability to provide informed consent * Minors * Pregnant women
References
Publications (0)
Data not yet available
No reference posted for this study.