Clinical trial · Observational

Study of DNA Samples From Patients With Multiple Myeloma

Proposal for Combining ECOG Myeloma Trial SNP Data

NCT00898040CI-TRIAL-00027699completedClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA samples from patients with multiple myeloma.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Multiple Myeloma and Plasma Cell Neoplasm	—	UNRESOLVED	—

Interventions

Interventions (1)

Intervention	Type	Mapped drug	Match
polymorphism analysis	Genetic	—	UNRESOLVED

Design

Arms and outcomes

Arms (0)

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Primary outcomes (5)

measure
Increased frequency of ≥1 polymorphic alleles associated with clinical endpoints using custom myeloma SNP chip analysis of banked DNA samples from patients with multiple myeloma
timeFrame
1 month
measure
SNPs associated with toxicities caused by individual genetic variations affecting drug activation, distribution, metabolism, and export (ADME)
timeFrame
1 month
measure
SNPs associated with response
timeFrame
1 month
measure
SNPs associated with bone disease
timeFrame
1 month
measure
SNPs associated with epidemiology (i.e., risk factors for the development of multiple myeloma)

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 18 Years
Maximum age: 120 Years

Show eligibility criteria text

DISEASE CHARACTERISTICS:

* Diagnosis of multiple myeloma
* DNA samples banked from other ECOG studies (and other clinical trial groups \[e.g., SWOG and MRC\])

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

References

Publications (0)

Data not yet available

No reference posted for this study.