Clinical trial · Observational
Studying Cells Collected Through Ductal Lavage in Women Undergoing Surgery for Ductal Carcinoma In Situ or Other Breast Cancer
Breast Cancer Prevention by Inducing Apoptosis in DCIS Using Breast Ductal Lavage
NCT00896857CI-TRIAL-00026464completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is evaluating cells collected through ductal lavage in women undergoing surgery for ductal carcinoma in situ or other breast cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| breast duct lavage | Procedure | — | UNRESOLVED |
| immunoenzyme technique | Other | — | UNRESOLVED |
| immunohistochemistry staining method | Other | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| polymerase chain reaction | Genetic | — | UNRESOLVED |
| protein expression analysis | Genetic | — | UNRESOLVED |
| reverse transcriptase-polymerase chain reaction | Genetic | — | UNRESOLVED |
| RNA analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Expression pattern of the programmed cell death (PCD) regulatory genes bcl-2, bax, and bcl-xL in primary ductal carcinoma in situ (DCIS) cultures
- measure
- Induction of PCD by antisense oligonucleotides and/or tamoxifen citrate in primary DCIS cell cultures
- measure
- Expression pattern of the PCD regulatory genes bcl-2, bax, and bcl-xL in cells obtained by breast ductal lavage
- measure
- Induction of PCD by antisense oligonucleotides and/or tamoxifen citrate in cells obtained by breast ductal lavage
Eligibility
Eligibility (as posted)
- Sex
- Female
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Agrees to undergo breast surgical procedure AND meets one of the following criteria: * Scheduled to undergo breast biopsy based on suspicious mammographic or clinical breast examination findings * Diagnosis of ductal carcinoma in situ (DCIS) or carcinoma in the breast to be studied (opposite breast may also be studied) * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Female * Pre- or post-menopausal * Not currently pregnant or pregnant within the past 12 months * Must not have lactated within the past 12 months * No active infection or inflammation in the breast to be studied * No known allergy to lidocaine, prilocaine, or marcaine (bupivacaine) PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior subareolar surgery or other breast procedure that may disrupt the ductal system within 2 cm of the nipple in the breast to be studied * No prior breast implant that disrupts the ductal architecture in the breast to be studied * No prior silicone injections in the breast to be studied * No prior radiotherapy to the breast to be studied * No chemotherapy within the past 6 months * Concurrent prophylactic chemotherapy allowed * No concurrent participation in another research study that may conflict with or affect the outcome of this study
References
Publications (0)
Data not yet available
No reference posted for this study.