Clinical trial · Observational
Genes and Other Risk Factors for Second Primary Breast Cancer in Women With Breast Cancer and Their Female Family Members and Friends
The British Breast Cancer Study - National Cancer Research Network Cohort (BBC-NCRN)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of blood, urine, and tumor tissue in the laboratory from patients with cancer and their female relatives and friends may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at genes and other risk factors for second primary breast cancer in women with breast cancer and in their female family members and friends.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DNA analysis | Genetic | — | UNRESOLVED |
| genetic linkage analysis | Genetic | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| loss of heterozygosity analysis | Genetic | — | UNRESOLVED |
| medical chart review | Other | — | UNRESOLVED |
| polymorphism analysis | Genetic | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Prevalence of polymorphisms in candidate genes in contralateral patients and controls
- measure
- Prevalence of alleles in breast cancer patients from multiple-case families and those in blood-unrelated family controls
- measure
- Linkage analysis to detect new susceptibility genes in larger multiple-case families combined with data on families previously collected by the Institute of Cancer Research
- measure
- Relationships between candidate gene polymorphisms and hormone levels in relatives and controls
Secondary outcomes (1)
- measure
- Average hormone levels in contralateral patients' first-degree relatives and controls
Eligibility
Eligibility (as posted)
- Sex
- Female
- Maximum age
- 70 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Women who have been diagnosed with contralateral or unilateral breast cancer * Family controls, including sisters and adult daughters of contralateral cases, female relatives by marriage * Unrelated controls (i.e., friends) * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Pre- or postmenopausal PRIOR CONCURRENT THERAPY: * Not specified
References
Publications (0)
Data not yet available