Clinical trial · Interventional
Laparoscopic Versus Open Left Colonic Resection
Laparoscopic vs. Open Left Colonic Resection: a Randomized Monocentric Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main goal of this study is to clarify if laparoscopy (LPS) could become the standard approach in patients undergoing left colonic resection. 268 patient candidates to left colonic resection were randomly assigned to LPS (n=134) or open (n=134) approach. Postoperative care protocol was the same in both groups. Trained members of the surgical staff who were not involved in the study registered 30-day postoperative morbidity. Cost-benefit analysis was based on hospital costs. Long-term morbidity, quality of life, and 5-year survival have also been evaluated.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Disease | — | UNRESOLVED | — |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laparoscopic left colonic resection | Procedure | — | UNRESOLVED |
| open left colonic resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- LPS
- description
- laparoscopic left colonic resection
- interventionNames
- Procedure: laparoscopic left colonic resection
- type
- ACTIVE_COMPARATOR
- label
- Open
- description
- open left colonic resection
- interventionNames
- Procedure: open left colonic resection
Primary outcomes (1)
- measure
- short-term morbidity rate
- timeFrame
- 30 days
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age \> 18 years * suitability to elective surgery Exclusion Criteria: * cancer infiltrating adjacent organs assessed by computed tomography * cardiovascular dysfunction (New York Heart Association class \> 3) * respiratory dysfunction (arterial pO2 \< 70 mmHg) * hepatic dysfunction (Child-Pugh class C) * ongoing infection * plasma neutrophil level \< 2.0x109/L
References
Publications (1)
- DERIVEDBraga M, Frasson M, Zuliani W, Vignali A, Pecorelli N, Di Carlo V. Randomized clinical trial of laparoscopic versus open left colonic resection. Br J Surg. 2010 Aug;97(8):1180-6. doi: 10.1002/bjs.7094. PMID 20602506