A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas

Inclusion Criteria:

* Patients must be ≥ 3 years of age and ≤ 30 years of age at the time of study entry.
* Diagnosis:

  * High-grade glioma;Patients must have had histologically verified anaplastic astrocytoma, glioblastoma multiforme or gliosarcoma.Patients with primary spinal cord tumors are eligible.
  * Diffuse intrinsic pontine glioma (DIPG) are eligible.
* Performance Level: Karnofsky ≥ 50% for patients \> 10 years of age and Lansky ≥ 50 for patients ≤ 10 years of age. Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.
* Prior Therapy: no prior anticancer therapy.
* Concomitant Medications: The use of steroids is permissible.
* Organ Function Requirements All patients must have adequate organ function as defined below.

  * Adequate Bone Marrow Function
  * Adequate Renal Function
  * Adequate Liver Function
* Adequate Blood Clotting Defined As: INR, Fibrinogen, and PTT \< Grade 2
* Central nervous system function. Patients with seizures may be enrolled if the seizures are well-controlled with non-enzyme inducing anticonvulsants.
* Informed Consent. Patients and/or parents/legal guardians must have signed an informed consent.

Exclusion Criteria:

* Patients with metastatic disease (i.e. M+ disease, or disease anywhere other than primary site).
* Patients with evidence of a new intracranial hemorrhage that is larger than a punctate size on baseline MRI scan.
* Allergies: Patients with a history of allergic reaction to Chinese hamster ovary cell products, or other recombinant human antibodies.
* Pregnant or breast feeding women will not be entered on this study.
* Patients of childbearing or child-fathering potential must be willing to use a medically acceptable form of birth control, which includes abstinence, while being treated on this study.
* Infection: Patients who require IV antibiotics at time of enrollment, or who are currently receiving treatment for Clostridium difficile infection are excluded.
* Thrombosis: Patients must not have been previously diagnosed with a deep venous or arterial thrombosis (including pulmonary embolism), and must not have a known thrombophilic condition.
* Serious or Non-Healing Wounds
* Surgical Procedures: Patients who have had major surgery should not receive the first dose of bevacizumab until 28 days after major surgery.
* Patients with uncontrolled systemic hypertension.
* Proteinuria with a urine protein (albumin)/creatinine ratio of ≥1.0.