Clinical trial · Observational
Iron Overload in Patients Undergoing Donor Stem Cell Transplant
Iron Overload in Allogeneic Hematopoietic Cell Transplantation
NCT00888316CI-TRIAL-00030618completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Learning about the effect of excess iron in the liver of patients undergoing donor stem cell transplant may help doctors plan treatment. PURPOSE: This study is investigating the effects of iron overload in patients undergoing donor stem cell transplant.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Allogeneic Hematopoietic Cell Transplantation | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Hematopoietic Stem Cell Transplantation | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| magnetic resonance imaging | Procedure | — | UNRESOLVED |
| Serum ferritin | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Without Iron Overload
- description
- Patients entering study without pre-HSCT iron-overload. Iron overload will be defined as liver ion concentration (LIC above normal (\>1.8 mg/g) on R2 magnetic resonance imaging (MRI) of the liver.
- interventionNames
- Procedure: magnetic resonance imaging
- Procedure: Serum ferritin
- label
- With Iron-Overload
- description
- Patients entering study with pre-HSCT iron-overload. Iron overload will be defined as liver ion concentration (LIC above normal (\>1.8 mg/g) on R2 magnetic resonance imaging (MRI) of the liver.
- interventionNames
- Procedure: magnetic resonance imaging
- Procedure: Serum ferritin
Primary outcomes (1)
- measure
- Overall Survival
- timeFrame
- 1 Year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Planning to undergo allogeneic hematopoietic stem cell transplantation using either myeloablative or reduced-intensity conditioning * Any diagnosis allowed * Not pregnant * Weight ≤ 350 lbs * Must be able to give written informed consent indicating the investigational nature of the study and its potential risks. Exclusion Criteria: * Claustrophobia * Other contraindication for MRI (e.g., cardiac pacemaker, implanted cardiac defibrillator, aneurysm clips, carotid artery vascular clamp, neurostimulator, insulin or infusion pump, or implanted drug infusion device)
References
Publications (0)
Data not yet available
No reference posted for this study.