EMD 521873 Plus Radiotherapy in Non Small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

* Histologically or cytologically confirmed NSCLC stage IIIb with malignant pleural effusion or stage IV
* Pulmonary primary tumor or at least one NSCLC metastasis in the lung measuring at least 1 cm in diameter and eligible for local radiation with 20 Gy
* Disease control (partial remission or stable disease) after 4 cycles of platinum-based first-line chemotherapy whereby the time between the last dose of first-line chemotherapy and start of trial treatment should not be longer than 8 weeks
* Male or female, aged ≥18 years of age
* Signed written informed consent
* Effective contraception for male and female subjects of childbearing age
* ECOG performance status 0 or 1
* Adequate hematological function defined by WBC ≥3 x 10\^9/L, neutrophils ≥1.5 x 10\^9/L, lymphocyte count ≥0.5 x 10\^9/L, platelet count ≥100 x 10\^9/L; hemoglobin ≥9 g/dL
* Estimated creatinine clearance ≥50 mL/min according to the Cockcroft - Gault formula or 24-h urine sampling
* Adequate hepatic function defined by a total bilirubin level ≤1.5 times the upper limit of normal (ULN), and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤5 x ULN

Exclusion Criteria:

* Requirement for immunosuppressive treatment with the exception of inhalative corticosteroids or low-dose systemic corticosteroids (prednisone equivalent dose ≤10 mg/day)
* Systemic autoimmune disease (e.g. lupus erythematodes, rheumatoid arthritis)
* Organ transplant recipients
* Active infections (including HIV, hepatitis B and C, tuberculosis)
* Known or clinically suspected brain metastases
* Active cardiovascular/cerebrovascular disease (e.g. symptomatic coronary vascular disease, congestive heart failure ≥ NYHA II, LVEF \<50%, ventricular arrhythmia requiring medication, myocardial infarction or stroke) within previous 6 months
* Pericardial effusion
* Major impairment in pulmonary function: forced expir¬atory volume in 1 second (FEV1) \<50% and diffusion capacity for carbon monoxide (DLCO) \<50% of normal limit
* Any other significant disease that in the Investigator's opinion would exclude the subject from the trial
* Known conditions associated with necroses of non-tumor bearing tissues (e.g. esophageal or gastroduodenal ulcers, ischemic bowel disease, chronic inflammations)
* Pregnancy or lactation
* Radiotherapy, chemotherapy, major surgery, biological therapy or any investigational drug within 30 days prior to the start of trial treatment
* Requirement for concurrent systemic anticancer treatment (chemotherapy, biological therapy)
* Pretreatment with anti-EGFR antibodies or tyrosine kinase inhibitors
* Participation in another interventional clinical trial within the past 30 days before start of trial treatment
* Known alcohol or drug abuse
* Any psychiatric condition that would prohibit the understanding or rendering of the informed consent
* Legal incapacity or limited legal capacity