Consolidation PET-based and Donor-based After Salvage Therapy in Patients With HL in Relapse or Refractory

Inclusion Criteria:

* Patients confirmed Hodgkin's lymphoma at refractory at first line therapy, relapse early or late;
* Age \> 18 years;
* Life expectancy \> 3 months;
* Cardiac, pulmonary, renal and liver functions with normal range;
* Written informed consent.

Exclusion Criteria:

* Any psychological, familiar or geographical conditions that could potentially hinder the compliance to the protocol;
* renal failure as creatinine\> 1.2 mg/dl or creatinine clearance \<60 ml/min;
* AST/ALT or bilirubin\> 2.5 times the norm;
* HCV positivity with signs of ongoing viral replication (HCV PCR + AST\>1.5-2x normal);
* Heart disease clinically significant: eg. severe hypertension not controlled, multifocal uncontrolled cardiac arrhythmias, symptomatic ischemic heart disease or congestive heart failure class NYHA class III-IV (Annex 2), previous acute myocardial infarction;
* Ventricular ejection fraction \<45%;
* decompensated diabetes mellitus not controlled by insulin therapy; Disease with significant pulmonary function defined as FEV1 \<65% of predicted or DLCO \<50% of predicted value;
* HIV positive patients;
* Patients with uncontrolled infection;
* Neoplasia in the last 3 years except carcinoma in situ uterus, neck and basal skin cancer or prostate cancer in early stage localized exeresi treated with surgery or brachytherapy with curative intent, a good prognosis DCIS breast treated with surgery alone;
* Drug addiction or alcoholism.