Clinical trial · Interventional
Preoperative Hyperthermia in Major Abdominal Surgery Patients
Preoperative Whole-Body Hyperthermia in Patients Undergoing Major Abdominal Cancer Surgery: A Randomized Pilot Study
NCT00876954CI-TRIAL-00020613completedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators hypothesize that preoperative hyperthermia improves postoperative complications and compare a placebo group with standard thermoregulatory management (normothermia) to a treatment group receiving 2,5 hours of hyperthermia (38.5-39.5 °C core temperature) in a randomized, single blinded, controlled trial.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hyperthermia | Procedure | — | UNRESOLVED |
| Normothermia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- Warming without increase in core temperature
- interventionNames
- Procedure: Normothermia
- type
- ACTIVE_COMPARATOR
- label
- Hyperthermia
- description
- Hyperthermia for 2,5 hours (39 °C core temperature)
- interventionNames
- Procedure: Hyperthermia
Primary outcomes (1)
- measure
- Immune Status
- timeFrame
- 24 hours after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Male and female patients, age 18 - 75 * Open abdominal, curative cancer surgery \> 2 h Exclusion Criteria: * Pregnancy * Chronic cortisone treatment * Ongoing chemotherapy * Acute infections, septic surgery * Palliative surgery (e.g. debulking only)
References
Publications (0)
Data not yet available
No reference posted for this study.