Sunitinib Tumor Levels in Patients Not on Enzyme-Inducing Anti-Epileptic Drugs Undergoing Debulking Surgery for Recurrent Glioblastoma

Inclusion Criteria:

* Histologically confirmed glioblastoma
* 18 years of age or older
* Karnofsky Performance Status 60 or greater
* Patient must be on no anti-epileptic drugs (AED) or AED that are non-enzyme inducing (NEIAED)
* There is no limit to the number of prior chemotherapy regimens
* No concurrent malignancy except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix or breast. Patients with prior malignancies must be disease-free for 5 years or more
* Mini-mental status examination score of 15 or less
* Resolution of all acute toxic effect of prior chemotherapy, radiotherapy, or surgical procedures to grade 1 or less
* Adequate organ function as outlined in the protocol

Exclusion Criteria:

* Major surgery within 4 weeks of starting the study treatment
* Radiation therapy within 3 months of starting the study treatment
* Chemotherapy within 4 weeks (within 6 weeks for nitrosoureas) prior to entering the study
* Concurrent treatment on another clinical trial. Supportive care trials or non-treatment trials are allowed
* Any of the following within the 6 months prior to study drug administration: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure. stroke or transient ischemic attack, or pulmonary embolism
* Ongoing cardiac dysrhythmias of NCI CTCAE grade 2 or greater
* Prolonged QTc interval on baseline EKG
* Hypertension that cannot be controlled by medications
* Patients must not have a known coagulopathy that increases risk of bleeding or a history of clinically significant hemorrhages in the past
* Patients must be on therapeutic doses of anti-coagulants or anti-platelet agents while taking sunitinib
* Grade 3 systemic hemorrhage within 4 weeks fo starting the study treatment
* Patients whose MRI scan shows clinically significant intratumoral or peritumoral hemorrhage
* Pre-existing thyroid abnormality with thyroid function that cannot be maintained in the normal range with medication
* Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness or active infection
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into this study
* Concomitant use of ketoconazole and other agents known to induce CYP3A4
* Pregnancy or breastfeeding
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib