Clinical trial · Observational
Serum, Plasma, DNA and Tissue Bank in Chronic Obstructive Pulmonary Disease and Lung Cancer
Serum, Plasma, DNA and Tissue Bank of Patients With Chronic Obstructive Pulmonary Disease, Lung Cancer and Smoking Controls.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A biobank of Serum, plasma, DNA samples together with clinical information including specific questionnaires, complete pulmonary function and chest CT-scan, is prospectively collected in patients seen at the investigators' clinical service. The objective is to study candidate gene pathways in COPD and or lung cancer and to associate them with the clinical characteristics and phenotypes of COPD/emphysema and lung cancer. In subgroups of well characterised patients, other biological materials are also collected (lung tissue biopsies, peripheral blood mononuclear cells).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Obstructive Pulmonary Disease | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Smoking controls
- description
- Smokers without lung cancer and without COPD
- label
- COPD patients
- description
- Smokers with COPD but without lung cancer
- label
- Lung cancer patients
- description
- smokers - never smokers with lung cancer
Primary outcomes (1)
- measure
- Serological, cytological, histological and genetic analysis of biomarkers or genes which are involved in the pathogenesis of COPD/Emphysema/Lungcancer.
- timeFrame
- 0-1-3-6 years
- description
- All cases are prospectively collected in University hospital Leuven, Belgium. Of enrolled subjects data are collected at 0,1,3 and 6 years interval
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
Show eligibility criteria text
Inclusion Criteria for smokers: * A smoking history of at least 15 pack years and age of 50 years or older * Complete pulmonary function on day of visit * Chest CT-scan within one year of enrollment * 4 weeks from exacerbation Exclusion Criteria for smokers: * Less than 15 pack years * Younger than 50 year * Other pulmonary diseases interfering with CT or pulmonary function * Asthma Inclusion Criteria for lung cancer patients: * new diagnosis of proven lung cancer * chest CT scan within 2 months of enrollment * Complete pulmonary function Exclusion Criteria for lung cancer patients * not able to perform pulmonary function * Absence of histological diagnosis of lung cancer
References
Publications (0)
Data not yet available