Clinical trial · Observational
Characterization of Receptors in Non-functioning Pituitary Macroadenomas
Characterization of Receptors Present in Non-functioning Pituitary Macroadenomas by Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR)
NCT00852501CI-TRIAL-00009958unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Characterization of receptors present in non-functioning pituitary macroadenomas by Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR) would assist with targeted medical therapy based on the information obtained by immunohistochemistry and RT-PCR.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Tumor | Pituitary Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| To perform RT-PCR on the tissue obtained during surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Non-functioning pituitary macroadenoma
- description
- The performance of surgery is the standard of care in the management of non-functioning pituitary macroadenomas. The tissue obtained during surgery is routinely sent for histopathological examination. A piece of the tissue will undergo receptor characterisation via RT-PCR.
- interventionNames
- Other: To perform RT-PCR on the tissue obtained during surgery
Primary outcomes (1)
- measure
- To determine the expression of hormonal receptors in clinically non-functioning pituitary macroadenomas by RT - PCR and immunohistochemistry.
- timeFrame
- 2 years
Secondary outcomes (1)
- measure
- To correlate the clinical, hormonal and radiological characteristics of the patients with pituitary tumors with the hormonal receptors status.
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Adults, both males and females age 18 years old or more 2. Pituitary tumor more than 10 mm in diameter diagnosed by MRI 3. No clinical or laboratory evidence of pituitary hormone oversecretion (non-functioning pituitary macroadenoma) Exclusion Criteria: 1. Subjects with pituitary tumors less than 10 mm in diameter 2. Subjects with clinical or laboratory evidence of hormone oversecretion 3. Presence of dementia
References
Publications (0)
Data not yet available
No reference posted for this study.