Clinical trial · Interventional
A Trial of Complete Versus Selective HepaticVascular Clamping in Hepatectomy
A Prospective Randomized Controlled Trial of Complete Versus Selective HepaticVascular Clamping in Hepatectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Intraoperative bleeding remains a major concern during liver resection. Pringle maneuver is the most frequently used method to occlude inflow blood of the liver.However, experimental and clinical studies have shown than even short periods of clamping produce some degree of ischemia-reperfusion injury that can result in hepatocellular damage,this damage being especially important in patients with abnormal liver parenchyma such as steatosis and cirrhosis. The aim of this study was to evaluate whether the use of selective vascular clamping should be generalized to HCC patients and help to reduce the ischemia-reperfusion injury.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hemihepatic vascular Clamping | Procedure | — | UNRESOLVED |
| Portal vein occlusion | Procedure | — | UNRESOLVED |
| Pringle's Maneuver | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Pringle's Maneuver
- description
- Patients with HCC received Pringle's Maneuver in hepatectomy.
- interventionNames
- Procedure: Pringle's Maneuver
- type
- EXPERIMENTAL
- label
- Hemihepatic vascular Clamping
- description
- Patients with HCC received Hemihepatic vascular Clamping in hepatectomy
- interventionNames
- Procedure: Hemihepatic vascular Clamping
- type
- EXPERIMENTAL
- label
- portal vein occlusion
- description
- Patients with HCC received portal vein occlusion in hepatectomy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. with a clinical diagnosis of primary liver cancer, without any adjuvant therapy; 2. age:18-70years; 3. suitable for partial hepatectomy without other malignancies; 4. compensated cirrhosis with Child-Pugh class A, or B. Exclusion criteria: 1. reject to attend； 2. with any preoperative adjuvant therapy. 3. with intrahepatic or extrahepatic malignancies; 4. cirrhosis with Child-Pugh class C
References
Publications (0)
Data not yet available