The Effects of Adding a Home Exercise Program to a Clinical Physical Therapy Program on Cancer-Related Fatigue

Inclusion Criteria:

1. Greater than 18 years old on day of enrollment, male or female.
2. Histological confirmation of a high grade glioma (HGG). The patient's treatment plan must include plans for concurrent radiation and chemotherapy at the University of Florida.
3. Patients otherwise meeting standard medical criteria for referral to physical therapy.
4. Physically capable of trial participation, defined as:

   * Ambulatory, without assist-devices.
   * Able to maintain a specified walking pace for 15-30 minutes.
5. Adequate medical health to participate in this study.
6. Absence of factors that have been documented to possibly confound the assessment of fatigue:

   * Hematocrit (Hct) \<30.
   * Thyroid Stimulating Hormone (TSH) \> 2.5 wnl.
7. Absence of other factors, such as inadequate nutritional level, pain control, electrolyte levels, depression, that are felt insufficient for trial participation.
8. Karnofsky Performance Status \>60 or ECOG Performance Status \<2.
9. Ability to read and understand the patient informed consent form.
10. Ability and willingness to follow all requirements of the study including following all directions, taking medication as prescribed, and completion of all diaries and forms.
11. Signed informed consent.

Exclusion Criteria:

1. Failure to meet inclusion criteria
2. Physical and medical issues that would interfere with trial participation, such as:

   * History of major cardiopulmonary symptoms.
   * Orthopedic problem limiting participation.
   * Dementia or poor mental status.
   * Neurological deficit limiting participation physically or cognitively.