Study of IMC-11F8 in Participants With Colorectal Cancer

Inclusion Criteria:

* Histologically-confirmed, EGFR-detectable or EGFR-undetectable CRC
* Locally-advanced unresectable or metastatic adenocarcinoma of the colon or rectum
* At least 1 unidimensional-measurable target lesion by computed tomography (CT) scan or magnetic resonance imaging (MRI); target lesion(s) must not lie within an irradiated area
* Age ≥18 years
* Life expectancy of ≥6 months
* Eastern Cooperative Oncology Group (ECOG) performance status ≤2 at study entry
* Adequate hematologic function, as evidenced by an absolute neutrophil count (ANC) ≥1.5 x 10\^9 liter (L), hemoglobin ≥10 grams per deciliter (g/dL), and platelets ≥100 x 10\^9/L
* Adequate hepatic function as defined by a total bilirubin ≤1.5 milligrams per deciliter (mg/dL), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 x upper limit of normal (ULN) (or 5.0 x ULN in the case of liver metastases), and alkaline phosphatase (AP) ≤2.5 x ULN (or 5.0 x ULN in the case of liver metastases)
* Adequate renal function as defined by a serum creatinine ≤1.5 x ULN, creatinine clearance ≥ 60 milliliters per minute (mL/min), or serum albumin ≥lower limit of normal (LLN)
* Participant's relevant toxicities/effects of prior therapy \[surgery/radiation therapy (RT)\] must have recovered to a stable or chronic level
* Participant agrees to use adequate contraception during the study period and for 4 weeks after the last dose of study treatment. Participants must notify the principal investigator if they themselves or their partner becomes pregnant.
* Participant has provided signed Informed Consent

Exclusion Criteria:

* Has received prior systemic chemotherapy for locally-advanced unresectable or metastatic CRC.
* Has received prior radiotherapy to \>25% of bone marrow
* Has documented and/or symptomatic brain metastases
* Has participated in clinical studies of non-approved experimental agents or procedures within 12 weeks of study entry
* Has received previous therapy with monoclonal antibodies
* Has received previous therapy with any agent that targets the EGFR
* Has serious concomitant medical conditions including active uncontrolled infection or cardiac disease, which in the opinion of the investigator, could compromise the participant or study.
* On chronic non-topical corticosteroid treatment for \>6 months at doses \>10 milligrams per day (mg/day) of prednisolone or equivalent before study entry, which in the opinion of the investigator could compromise the participant or the study
* Has a known dihydropyrimidine dehydrogenase deficiency
* Has a known allergy to any of the treatment components
* Has an acute or subacute intestinal occlusion
* Has peripheral neuropathy ≥Grade 2
* Has a history of other malignancies, with the exception of curatively treated non-melanoma skin cancer or carcinoma in situ of the cervix
* If female, is pregnant (confirmed by urine or serum beta human chorionic gonadotropin test) or breast-feeding
* Has received a prior autologous or allogeneic organ or tissue transplantation
* Has interstitial pneumonia or interstitial fibrosis of the lung
* Has pleural effusion or ascites that causes ≥Grade 2 dyspnea
* Has psychological, familial, sociological, or geographical conditions which do not permit adequate study follow-up, compliance with the protocol, or signature of Informed Consent