Clinical trial · Interventional
Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing
NCT00833508CI-TRIAL-00020938completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cardiopulmonary exercise testing | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Test arm
- description
- Patients undergoing preoperative chemoradiotherapy will have their exercise capacity measured before and after chemoradiotherapy.
- interventionNames
- Other: Cardiopulmonary exercise testing
Primary outcomes (1)
- measure
- Change of Anaerobic threshold of 1.5ml/min/kg or more
- timeFrame
- 6 weeks
Secondary outcomes (1)
- measure
- Operative outcome
- timeFrame
- 6-10 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age greater than 65 * Colorectal cancer requiring preoperative chemoradiotherapy Exclusion Criteria: * Inability to walk, or exercise on a bicycle or treadmill * Inability to understand instructions for CPET testing * ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery) * Contraindications to Exercise Testing * Myocardial infarction occurring 10 days or less before CPX testing * Symptomatic arrythmias * Left Main Stem coronary disease of \>50% * Severe hypertension (SBP\>180mmHg) * Resting SpO2 \<85% * Acute cardiac inflammatory conditions (myocarditis, pericarditis) * Unstable angina with symptoms within 4 days * Dissecting aneurysm of aorta * Acute pyrexial illness * Thyrotoxicosis * Syncopal episodes * Lower limb thrombosis (arterial or venous)
References
Publications (1)
- BACKGROUNDOlder P, Smith R, Courtney P, Hone R. Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing. Chest. 1993 Sep;104(3):701-4. doi: 10.1378/chest.104.3.701. PMID 8365279