Comparison of Brivanib and Best Supportive Care to Placebo for Treatment of Liver Cancer for Those Subjects Who Have Failed Sorafenib Treatment

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Inclusion Criteria:

* Histologic or cytologic confirmed diagnosis of HCC
* Advanced disease defined as (i) disease not eligible for surgical or loco-regional therapy or (ii) disease progressive after surgical or loco-regional therapy
* Patient has failed ≥ 14 days of Sorafenib treatment
* Cirrhotic status of Child-Pugh Class A or B with a score of 7
* Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, 2
* Subjects who have a life expectancy of at least 8 weeks
* Adequate hematologic, hepatic, and renal function

Exclusion Criteria:

* women of childbearing potential (WOCBP) who are unwilling or unable to use an acceptable method to avoid pregnancy
* Previous or concurrent cancer that is distinct in primary site
* History of active cardiac disease
* Thrombotic or embolic events within the past 6 months
* Any other hemorrhage/bleeding event \> Common Terminology Criteria for Adverse Events (CTCAE) Grade 3 within 4 weeks
* Inability to swallow tablets or untreated malabsorption syndrome
* History of human immunodeficiency virus (HIV) infection
* Prior use of systemic investigational agents for HCC (except for Sorafenib)