Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) With Busulfan, Fludarabine and Thymoglobulin

Inclusion Criteria:

1. Patients age \>/=18 to \</= 65 years.
2. Diagnosis of AML in first or greater remission, first or subsequent relapse, or primary induction failure; MDS with intermediate or high risk International Prognostic Scoring System (IPSS) score having failed to respond or recurred after chemotherapy; in remission or having active disease after treatment; AML arising from MDS; or CML which has failed to respond to imatinib or other tyrosine kinase inhibitor and has had \>5% blasts in the blood or bone marrow. Patients receiving second transplants after relapse are considered in the relapse group.
3. White Blood Count (CBC) \</= 20 \* 10\^9/l.
4. Patients should have a histocompatible, related or unrelated volunteer donor available. A histocompatible donor is defined as HLA matched related donor or an unrelated donor matched for HLA- A, B, C, and DR antigens by high-resolution DNA techniques.
5. Zubrod performance status 0 or 1, or Karnofsky performance status 90-100%.
6. Left ventricular ejection fraction \>/= 45 %. No uncontrolled arrhythmias or uncontrolled symptomatic cardiac disease.
7. No symptomatic pulmonary disease. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and diffusion capacity of carbon monoxide (DLCO) \>/= 50 % of expected, corrected for hemoglobin.
8. Serum creatinine \</=1.5 mg/dl.
9. Serum glutamic pyruvic transaminase (SGPT) \</= 200 IU/ml unless related to the malignancy.
10. Total serum bilirubin \</=1.5 mg/dl (unless Gilbert's syndrome) and alkaline phosphatase \</=2.5 times laboratory standard upper limit of normal (ULN).
11. Patient or patient's legal representative able to sign informed consent.

Exclusion Criteria:

1. History of HIV positive.
2. Positive Beta human chorionic gonadotropin (HCG) test in a woman with child bearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization.
3. Pleural/pericardial effusion or ascites estimated \>/= 1 liter.
4. Uncontrolled infection, not responding to appropriate antimicrobial agents after seven days of therapy.
5. History of acute hepatitis, chronic active hepatitis or cirrhosis.
6. Patients with class 3 or 4 angina (New York Heart Association (NYHA) criteria).