Research on Surgery and Micro-Invasive Treatment in Recurrent Primary Liver Cancer

In this study, we intend to divide the subjects who have been confirmed recurrent HCC into two groups: Group A: treatment with pure surgery or Group B: treatment with pure radio frequency. We will compare the non-tumor survival time, long-term survival rate between the two groups, summarize the merits and demerits of both groups, and try to establish a standardized therapy and treatment for the this kind of patients through prospective studies on the molecular biological difference of pathological samples between the first and second surgeries.

Sex

All

Minimum age

20 Years

Maximum age

60 Years

Inclusion Criteria:

1. 20\~60 years old;
2. diagnosed HCC pathologically, and confirmed recurrent HCC through ultrasonic B, CT, MRI or DSA test;
3. has a good condition in vital organs such as heart, lung, and kidney;
4. has a good liver function: Child A level, or nearly A level after hepatoprotection treatment;
5. solitary small cancer focus (diameter \<5cm), or the number of recurrent HCC focus is no more than three and all of them grow in the same lobe of liver;
6. without jaundice (not including jaundice in the bile ducts), without ascites or extensive metastasis outside the liver;
7. without invasion to portal vein.

Exclusion Criteria:

1. subjects refuse to participate in this study;
2. subjects cannot be followed up regularly;
3. subjects with severe heart, lung, kidney diseases;
4. subjects with liver CP level B or C, and serum creatinine ≥2×ULN;
5. subjects with severe bone marrow depression, such as neutrophil counting is lower than 1.5 × 109.

• DERIVEDXia Y, Li J, Liu G, Wang K, Qian G, Lu Z, Yang T, Yan Z, Lei Z, Si A, Wan X, Zhang H, Gao C, Cheng Z, Pawlik TM, Wang H, Lau WY, Wu M, Shen F. Long-term Effects of Repeat Hepatectomy vs Percutaneous Radiofrequency Ablation Among Patients With Recurrent Hepatocellular Carcinoma: A Randomized Clinical Trial. JAMA Oncol. 2020 Feb 1;6(2):255-263. doi: 10.1001/jamaoncol.2019.4477. PMID 31774468