Safety and Tolerability of CHR-2845 to Treat Haematological Diseases or Lymphoid Malignancies

Inclusion Criteria:

1. Signed, informed consent
2. Confirmed malignant haematological disease or lymphoid malignancy refractory to standard therapy or for which no standard therapy exists, including acute leukemias, MDS, CML, CLL, CMML, multiple myeloma and Non-Hodgkin's Lymphomas/Hodgkin's disease
3. Patients shall have recovered from all acute adverse effects of prior therapies, with the exception of alopecia and grade 1 neuropathy where recovery is not required
4. Adequate bone marrow, hepatic and renal function including the following:

   1. Patients with high blast counts can be included if they can be controlled by the use of hydroxyurea (500 mg -3,000 mg daily).
   2. Total bilirubin ≤ 1.5 x upper normal limit, excluding cases where elevated bilirubin can be attributed to Gilbert's Syndrome
   3. AST (SGOT), ALT (SGPT) ≤ 2.5 x upper normal limit
   4. Creatinine ≤ 1.5 x upper normal limit
5. Age ≥ 18 years
6. Performance status (PS) ≤ 2 - Eastern Cooperative Oncology Group (ECOG) scale
7. Estimated life expectancy greater than 3 months
8. Female patients with reproductive potential must have a negative serum pregnancy test within 7 days prior to start of trial. Both women and men must agree to use a medically acceptable method of contraception throughout the treatment period and for 3 months after discontinuation of treatment.

Exclusion Criteria:

1. Patients receiving anti-cancer therapy or use of other investigational agents within 21 days prior to trial entry (or a longer period depending on the defined characteristics of the agents used. Bisphosphonates for bone disease and corticosteroids are permitted provided the dose does not change during the trial. Patients must have recovered from all transient toxicity induced by prior therapy
2. Patients with co-existing active infection, graft versus host disease or serious concurrent illness
3. Patients who have failed to recover from or after a bone marrow transplantation or haematopoietic stem cell transplantation
4. The following diseases are excluded: Burkitt's lymphoma, primary effusion lymphoma, precursor B-cell lymphoblastic lymphoma, symptomatic central nervous system (CNS) lymphoma, CML blast crisis
5. Patients with significant cardiovascular disease as defined by:

   1. history of congestive heart failure requiring therapy
   2. history of angina pectoris requiring treatment or myocardial infarction within 6 months prior to trial entry
   3. presence of severe valvular heart disease
   4. presence of an atrial or ventricular arrhythmia requiring treatment
   5. Left Ventricular Ejection Fraction (LVEF) below the normal range at the study centre
   6. Uncontrolled hypertension
   7. A history of abnormal QTc intervals or an average QTc interval at screening ≥450 msec
6. Any medical or other condition that in the investigator's opinion renders the patient unsuitable for this study due to unacceptable risk
7. Psychiatric disorders or altered mental status precluding understanding of the informed consent process and/or completion of the necessary studies
8. Gastrointestinal disorders that may interfere with absorption of the study drug
9. Patients with known brain tumours or metastases
10. More than 6 prior chemotherapy regimens
11. Patients requiring growth factor support (erythropoietin, Granulocyte/monocyte Colony Stimulating Factor (GM/CSF), etc)
12. Patients requiring palliative radiotherapy within the last 4 weeks prior to study entry
13. Uncontrolled hypercalcaemia (CTCAE v3 grade 2 or higher)
14. Abnormal plasma potassium or magnesium levels (Common Terminology Criteria for Adverse Events (CTCAE) v3 grade 3 or greater) despite therapy
15. Pregnant or breast-feeding women