Treatment Of Radiation Retinopathy Trial

Inclusion Criteria:

* The eye was previously irradiated for treatment of a uveal melanoma;
* Decrease of visual acuity after irradiation therapy by more than 10 letters (ETDRS) and is now 20/40 or less;
* Vision decrease is considered to be due to central radiation retinopathy with significant macular edema or optic disc edema;
* Age 18 years or older;
* The patient is fully competent;
* Written informed consent to participate in the trial is given.
* Patient is not pregnant (or not fertile) and is willing to use contraceptives for the duration of the trial (one year)
* Patient is willing and able to return for follow-up.

Exclusion Criteria:

* Vision decrease is considered to be due to ischemic radiation retinopathy without macular edema or optic disc edema;
* Other, approved therapy indicated for treatment of condition;
* Presence of metastasis;
* Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the trial;
* Pre-existing retinopathy due to other disorders;