Clinical trial · Interventional
Pulmonary Surgery and Protective Mechanical Ventilation
NCT00805077CI-TRIAL-00011502VPPcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this trial is to evaluate the efficacy and the safety of lung protective ventilation during anesthesia in patients undergoing pneumonectomy or lobectomy for lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| mechanical ventilation | Procedure | — | UNRESOLVED |
| tidal volume | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- mechanical ventilation with low tidal volume (5 ml/kg of ideal body weight) plus PEEP
- interventionNames
- Procedure: mechanical ventilation
- type
- OTHER
- label
- 2
- description
- tidal volume of 10 ml/kg of ideal body weight without PEEP
- interventionNames
- Other: tidal volume
Primary outcomes (1)
- measure
- Major postoperative complications during the first 30 days after surgery
- timeFrame
- the first 30 days after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Primary lung cancer. * Elective Pneumonectomy or lobectomy or bilobectomy * Written informed consent Exclusion Criteria: * Patients undergoing surgical procedure other than pneumonectomy or lobectomy or bilobectomy * Mesothelioma * Liver cirrhosis * Chronic renal failure * Need for mechanical ventilation or non invasive ventilation (CPAP for obstructive sleep apnea syndrome for example) before surgery * Emergency surgery
References
Publications (1)
- DERIVEDMarret E, Cinotti R, Berard L, Piriou V, Jobard J, Barrucand B, Radu D, Jaber S, Bonnet F; and the PPV study group. Protective ventilation during anaesthesia reduces major postoperative complications after lung cancer surgery: A double-blind randomised controlled trial. Eur J Anaesthesiol. 2018 Oct;35(10):727-735. doi: 10.1097/EJA.0000000000000804. PMID 29561278