Clinical trial · Interventional
Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients
A Prospective Cohort Study to Evaluate the Impact of Preoperative Breast Magnetic Resonance Imaging (MRI) on Surgical Decision-Making in Young Patients With Breast Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Young women with breast cancer have an increased breast tissue density and conventional imaging tests such as mammography and breast ultrasound are less sensitive and specific for detecting breast cancer than in older breast cancer patients. Breast MRI is an emerging tool that has been proven to improve the ability to identify breast cancers by determining the extent of disease and also detect multifocal, multicentric and bilateral breast cancers. To date, the role of pre-operative breast MRI is not clearly defined. The investigators are proposing a study to evaluate the impact of preoperative breast MRI on surgical decision-making in breast cancer patients \<= 50 years. This may lead to improved characterization of breast cancers in these younger patients that may ultimately result in lower local recurrence rates in the future. The additional information attained through the breast MRI may also guide the use of radiation, chemotherapy and/or hormonal therapy in these patients.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Magnetic Resonance Imaging | — | UNRESOLVED | — |
| Preoperative MRI | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pre-operative bilateral breast MRI | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Does pre-operative magnetic resonance imaging (MRI) effect surgical management in young women with breast cancer
- timeFrame
- 3 months
Secondary outcomes (3)
- measure
- Proportion of patients requiring a second surgery due to positive tumour margins.
- timeFrame
- 3 months
- measure
- Incidence of multifocal or multicentric or bilateral breast cancer found on MRI
- timeFrame
- After surgery
- measure
- The correlation between MRI tumour size and the pathologic tumour size after surgery.
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- Female
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Female aged \<= 50 years * Histological proof of invasive breast cancer via fine needle aspiration or core needle biopsy * Premenopausal Exclusion Criteria: * Patient not considered an appropriate surgical candidate; i.e., patient is not well enough to have breast cancer surgery * Patient has had prior breast cancer surgery or an excisional biopsy of the newly diagnosed cancer * Patient has a contraindication to undergoing breast MRI (i.e., pacemaker, neurodefibrillator, metallic foreign bodies, etc.) * Patient has inflammatory breast cancer according to the standard clinical definition. This is a type of breast cancer in which there is evidence of erythema and/or edema. The skin of the breast may also have changes of peau d'orange. * Patient has locally advanced breast cancer according to the standard clinical definition. * Patient is pregnant * Patient has a psychiatric or addictive disorder that would preclude them from obtaining informed consent.
References
Publications (0)
Data not yet available