Efficacy and Safety of a PN Regimen Containing n-3 Fatty Acid in Patients Considered After GI Surgery

Inclusion Criteria:

* Patients considered for major surgery for gastric and colorectal cancer
* expected requirement for post operative PN or TPN of at least 7 days
* possibility of PN/TPN provision 1 day prior to surgery
* Age \>18 years old and \<80 years old
* Hemodynamically stable
* Written Informed consent

Exclusion Criteria:

* Participation in a clinical study with an investigational drug or an investigational medical device within one month prior to the start of study
* Patients with sepsis, severe sepsis or septic shock
* Known or suspected drug abuse
* Intrahepatic cholestasis
* General contraindications for infusion therapy such as acute pulmonary edema, hyperhydration and decompensated cardiac insufficiency
* Pregnancy (positive in urine) or lactation
* Autoimmune disease e.g. HIV
* Known hypersensitivity to egg-, soy-, and fish proteins or any of the ingredients of the investigational products
* Hemodynamic failure of any origin (hemorrhagic shock, myocardial infarction, cardiac failure)
* Alterations of coagulation (thrombocytes \<150000 /mm3), PT \< 50%, PTT \> 40 sec
* Ketoacidosis caused by Diabetes mellitus within 7 days prior to onset of study
* Renal insufficiency with serum creatinine \> 1.4 mg/dL (\>124 µmol/L)
* Patients with severe liver dysfunction with bilirubin \>2.5 mg/dL (\> 43 µmol/L)
* Lipid disorders, in particular fasting serum triglycerides \> 250 mg/dL (\>2.85 mmol/L),