Clinical trial · Interventional
Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma: A Prospective Randomized Controlled Trial
NCT00795782CI-TRIAL-00021763completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether the prophylactic ipsilateral central lymph node dissection is equally effective in the management of papillary thyroid microcarcinoma(PTMC) to the bilateral central lymph node dissection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Prophylactic central lymph node dissection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- UniCND
- description
- Limited/ipsilateral central lymph node dissection
- interventionNames
- Procedure: Prophylactic central lymph node dissection
- type
- ACTIVE_COMPARATOR
- label
- BiCND
- description
- Comprehensive/bilateral central lymph node dissection
- interventionNames
- Procedure: Prophylactic central lymph node dissection
- type
- NO_INTERVENTION
- label
- NoCND
- description
- No central lymph node dissection
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Age: 18 to 70 * Sonographically node-negative cytology confirmed thyroid papillary carcinoma * Tumor size less than 1 cm in sonography * Tumor confined to the one lobe of the thyroid gland * One who provides the informed consent Exclusion Criteria: * History of radiation treatment to head and neck area * History of other malignancy except thyroid cancer * Poor performance status (ECOG 3-4)
References
Publications (1)
- BACKGROUNDSon YI, Jeong HS, Baek CH, Chung MK, Ryu J, Chung JH, So YK, Jang JY, Choi J. Extent of prophylactic lymph node dissection in the central neck area of the patients with papillary thyroid carcinoma: comparison of limited versus comprehensive lymph node dissection in a 2-year safety study. Ann Surg Oncol. 2008 Jul;15(7):2020-6. doi: 10.1245/s10434-008-9928-8. Epub 2008 May 6. PMID 18459004