Magnetic Resonance Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors

Inclusion Criteria:

* Patient or family able and willing to give informed consent.
* Subjects with metastatic cancer to the brain who have failed at least one conventional therapy (surgery, stereotactic radiosurgery, and/or whole brain radiotherapy).
* Three or fewer previously treated or untreated lesion(s) in the brain.
* Tumor size ≤ 3.0 cm in largest diameter.
* MR imaging is not contraindicated for the patient.
* Lesion(s) are clearly defined on pre-therapy contrast enhanced MRI scans as determined by the treating surgeon.
* Able and willing to attend all study visits.
* Karnofsky Performance Scale score \>70 for patients over the age of 15.
* Lansky Play Scale \>70 for patients 15 years of age or younger.

Exclusion Criteria:

* Patients or family unwilling or unable to give written consent.
* Patients who cannot physically fit in, or are too heavy for, the MRI scanner.
* Patients with contra-indications to MRI imaging, such as, but not limited to, pacemakers or defibrillators, non-compatible aneurysm clips, shrapnel, or other internal ferromagnetic objects.
* Known sensitivity to gadolinium-DTPA.
* Based on Treatment Planning Imaging (MR and/or CT):

  * Brain edema and/or mass effect that causes midline shift or shift in wall of ventricle of more than 5 mm.
  * Lesions localized in the brain stem.
  * Lesions less than 5mm from primary branches of cerebral vessels, venous sinus, hypophysis or cranial nerves.
  * Evidence of recent (\<2 weeks) hemorrhage.
* Presence of more than 3 brain tumors at the time of enrollment.
* Symptoms and signs of increased intracranial pressure.
* Medical issues which prohibit the patient from undergoing surgery (as determined by the treating surgeon, anesthesiologist, IMPAC clinic, referring physician).
* Patients who are unable to receive corticosteroids.
* Positive pregnancy test for women of child-bearing age.