Clinical trial · Interventional
TOBI to Monitor Response to Neoadjuvant Therapy in Breast Cancer
Functional Metabolic Near-infrared Tomographic Optical Breast Imaging (TOBI) to Monitor Response to Neoadjuvant Therapy in Breast Cancer
NCT00783757CI-TRIAL-00028812completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research study is to see if Near-Infrared Tomographic Optical Breast Imaging (TOBI) scans can help monitor breast tumor response during treatment for breast cancer. The images created by the TOBI scan show changes in blood blow and oxygen levels in breast tissue.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Optical Imaging | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Optical Imaging
- description
- Tomographic Optical Imaging Arm
- interventionNames
- Device: Optical Imaging
Primary outcomes (1)
- measure
- To explore the feasibility of measuring optically derived parameters in the clinical setting.
- timeFrame
- 4 years
Secondary outcomes (2)
- measure
- To explore the changes before and after neoadjuvant therapy of additional parameters derived from dynamic and static optical imaging of primary breast cancer.
- timeFrame
- 4 years
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult female patients presenting to the MGH Cancer Center Gillette Center for breast cancer neoadjuvant therapy * Subject who have had or will have a clinically indicated pre-treatment breast MRI Exclusion Criteria: * Younger than 18 years of age * Open wounds on breast * Breast implants, because they may interfere with readings * Subjects who will be receiving preoperative therapy for \<28 days * Breast surgery or biopsy \< 10 days prior to optical imaging scan * Medical or psychiatric or other medical condition that the principal investigator believes may result in inability to complete the study * Bilateral breast cancers or a history of contralateral breast cancer
References
Publications (0)
Data not yet available
No reference posted for this study.